Can Östradiol help with Müdigkeit?

The provided context contains no direct evidence on whether estradiol can help with fatigue. Estradiol is a key female hormone, and low levels during menopause or certain cycle phases may contribute to fatigue. However, hormone therapy is not a simple 'supplement' and requires medical supervision due to risks (e.g., thrombosis, cancer). Observational studies suggest some benefit for energy, but RCT evidence is mixed. Without specific data from the given knowledge base, a conservative stance is warranted: do not self-prescribe estradiol for fatigue. Consult a healthcare provider for proper evaluation.