Evidence check: TSH in the context of longevity

TSH (thyroid-stimulating hormone) is a debated topic in longevity research. Some observational studies in centenarians show slightly elevated TSH levels, suggesting subclinical hypothyroidism might be linked to extended lifespan, possibly due to reduced metabolism and oxidative stress. However, the evidence is mixed: other studies find no association or even negative effects on cardiovascular health. Importantly, TSH alone is not a reliable longevity marker. Thyroid function is influenced by many factors (iodine status, age, medications, stress). Abnormal TSH levels should always be evaluated by a physician, as both hyper- and hypothyroidism are associated with increased mortality. The evidence for TSH as a direct longevity indicator is weak and based mainly on observational data. There are no validated recommendations to manipulate TSH for anti-aging purposes.