Can BDNF help with Müdigkeit?

BDNF (Brain-Derived Neurotrophic Factor) is often linked to neuroplasticity and energy regulation. Some studies report lower BDNF levels in chronic fatigue, but evidence for direct anti-fatigue effects of BDNF supplements is weak. BDNF is a protein that does not easily cross the blood-brain barrier, making oral supplementation questionable. Lifestyle factors like exercise, sleep, and omega-3 intake can support endogenous BDNF production. Genetics (e.g., BDNF Val66Met) influence baseline BDNF activity, but the effect on fatigue is small and not clinically actionable. Be cautious of exaggerated marketing claims. Evidence: mostly mechanistic; no robust clinical data for direct fatigue relief.