Evidence check: COMT in the context of Müdigkeit

The provided MyBody-X knowledge does not include COMT markers. COMT (catechol-O-methyltransferase) degrades dopamine and norepinephrine; the common Val158Met variant (rs4680) is linked to altered stress sensitivity and cognitive performance, but effects on fatigue are small, inconsistent, and heavily modulated by sleep, diet, and stress. Direct-to-consumer tests marketing COMT as a 'fatigue gene' overstate clinical utility. Evidence is primarily mechanistic and from GWAS, not from controlled intervention trials. Fatigue is multifactorial – hormones, microbiome, nutrient status, and lifestyle are more impactful than a single gene. A COMT test alone provides no actionable insight. Safety note: Not a medical diagnosis; persistent fatigue warrants clinical evaluation.