Is hsCRP useful for Schlaf?

The usefulness of hsCRP for sleep assessment is not well supported by current evidence. hsCRP is a non-specific inflammatory marker that can be elevated by many factors, including poor sleep or sleep disorders. However, the association is not strong enough to recommend hsCRP as a standalone biomarker for sleep quality or sleep disorders. Elevated hsCRP may indicate systemic inflammation, which has been linked to sleep disturbances in observational studies, but causality is unclear. In clinical practice, hsCRP is primarily used for cardiovascular risk assessment, not for sleep diagnostics. Genetic variants like rs3789327 in BMAL1 have only a tiny effect on chronotype and metabolism and are not actionable alone. Sleep hygiene and lifestyle factors are far more important. A single hsCRP test cannot diagnose a sleep disorder or guide specific therapy. If hsCRP is elevated, other causes such as infection or chronic inflammation should be ruled out. For comprehensive sleep evaluation, sleep diaries, actigraphy, or polysomnography are more appropriate. The evidence for hsCRP in the sleep context is best classified as 'practice' (clinical practice but not specifically validated for this purpose).