Is FUT2 useful for skin aging?

Whether FUT2 (secretor status) is useful for skin aging is not supported by strong evidence. FUT2 determines the expression of ABO antigens in body fluids and on mucosal surfaces. Some research suggests that secretor status may influence the skin microbiome composition and potentially affect skin barrier function and inflammation—both relevant to aging. However, direct evidence linking FUT2 to clinically meaningful skin aging outcomes is weak, mostly based on mechanistic plausibility or small observational studies. Direct-to-consumer genetic tests that include FUT2 cannot provide validated predictions about skin aging. Interpretation should be cautious, as lifestyle, UV exposure, and skincare have far greater impact. Without robust human studies, the utility of FUT2 for skin aging remains speculative.