Myths vs facts: VDR and Langlebigkeit

The claim that VDR variants directly determine longevity is a myth. The vitamin D receptor (VDR) is involved in calcium metabolism, immune function, and cell division – factors that could theoretically influence lifespan. Some association studies (e.g., rs2228570, rs1544410) show weak links to age-related diseases like osteoporosis or cancer, but effect sizes are small and often not replicated. A direct causal effect on maximum lifespan is not established. Evidence is mostly from GWAS with small effects or mechanistic hypotheses. Moreover, VDR status is confounded by environmental factors (vitamin D levels, sun exposure). A DNA test for VDR variants alone provides no clinically actionable information on personal longevity. Measuring blood 25(OH)-vitamin D is more useful. Bottom line: VDR is an interesting candidate but not a 'longevity gene.' Evidence is moderate and insufficient for recommendations.