How are BDNF and Langlebigkeit related?

BDNF (Brain-Derived Neurotrophic Factor) is a protein crucial for neuronal survival and growth. Its link to longevity is indirect and mediated through several pathways: it supports neuroplasticity, protects against age-related cognitive decline, and influences energy metabolism. Studies suggest that higher BDNF levels are associated with lower all-cause mortality, especially in cardiovascular and neurodegenerative contexts. However, the evidence is moderate—mostly observational and GWAS-based, not from randomized trials. The effect of single BDNF gene variants (e.g., Val66Met) on lifespan is small and heavily modulated by lifestyle factors like exercise, diet, and stress. Therefore, a direct DNA test for BDNF variants is not a reliable predictor of individual longevity. BDNF is better viewed as a biomarker of healthy aging rather than a 'longevity gene.' In summary, BDNF plays a role in the longevity puzzle, but its predictive power is limited and context-dependent.