What role does FTO play in skin aging?

FTO (Fat Mass and Obesity-Associated gene) is primarily known for its role in body weight regulation and appetite. The common variant rs9939609 (A-allele) is associated with a slightly increased BMI. There is no robust, direct scientific evidence linking FTO to skin aging. Most studies focus on obesity and metabolic traits; any connection to skin aging is indirect, possibly through obesity-related inflammation or glycation. Mechanistic research suggests FTO may influence adipocyte function, but skin-specific effects (e.g., collagen, elastin) remain unproven in human trials. Claims that FTO testing can predict skin aging are not supported by current evidence. The evidence level is weak/marketing. Consumers should be cautious of DNA tests that extrapolate from obesity genetics to skin health without direct validation.