What to watch with Homocystein and Fruchtbarkeit?

Homocysteine is a sulfur-containing amino acid; elevated levels (hyperhomocysteinemia) are associated with infertility in both women and men. In women, high homocysteine is linked to recurrent pregnancy loss, polycystic ovary syndrome (PCOS), and endometriosis. In men, it may impair sperm quality and motility. Common causes include genetic variants like MTHFR C677T and deficiencies in folate, vitamin B12, or B6. Supplementing with these B vitamins can lower homocysteine, but evidence that this directly improves fertility outcomes is mixed. It is advisable to measure homocysteine levels before supplementing. High-dose folic acid (>1 mg/day) should be used cautiously as it can mask B12 deficiency. Homocysteine is one piece of the fertility puzzle, not a standalone solution.