What can the Zöliakie Test tell you — and what not?

The MyBody-X Celiac Test analyzes HLA-DQ2 and HLA-DQ8 genotypes, which are strongly associated with celiac disease. A negative result effectively rules out celiac disease (negative predictive value >99%). However, a positive result does not mean you have the disease – about 30–40% of Europeans carry these risk alleles, yet only 1–3% develop celiac disease. The test is therefore a rule-out tool, not a diagnosis. It cannot replace duodenal biopsy or serological antibody tests (tTG-IgA). It also cannot distinguish between active celiac disease and silent/genetic predisposition. The evidence for the genetic association is strong (human-strong), but clinical interpretation requires a physician. MyBody-X states the test is not diagnostic. Consumers with a positive result should consult a gastroenterologist and maintain a gluten-containing diet before further testing. The test provides no information on disease severity, progression, or other autoimmune conditions. It is a useful screening aid, but not a substitute for established diagnostic pathways.