TSH (thyroid-stimulating hormone) is a key marker for thyroid function in men, though thyroid disorders are less common in men than in women. The typical reference range is 0.4–4.0 mU/L, but age-specific norms are important: older men may have slightly higher TSH without disease. Elevated TSH suggests hypothyroidism (fatigue, weight gain, low libido), while low TSH may indicate hyperthyroidism (palpitations, weight loss, anxiety). However, a single TSH value is insufficient for diagnosis; free T3, free T4, and antibodies (TPO, Tg) are needed. Biotin supplements can falsely lower measured TSH. Genetic tests for TSH-related variants (e.g., in TSHR, PDE8B) are not clinically validated for screening or treatment decisions. The evidence for such tests is weak (mechanistic/GWAS) and does not support routine use. Lifestyle factors, iodine status, and medication interactions are far more relevant. If TSH is abnormal, a full thyroid panel and endocrinologist evaluation are recommended.
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