Is CYP2D6 useful for longevity?

CYP2D6 is a drug-metabolizing enzyme involved in processing many medications (e.g., antidepressants, beta-blockers, tamoxifen). However, it plays no established role in longevity research. No robust human studies directly link CYP2D6 variants to extended lifespan. Some indirect associations have been proposed – such as effects on endogenous substrate metabolism or medication tolerability in older age – but these remain speculative and clinically unvalidated. Direct-to-consumer tests marketing CYP2D6 as a 'longevity gene' overstate the evidence. While CYP2D6 pharmacogenetics is useful for personalized dosing of certain drugs, it is not useful for predicting or optimizing healthy aging. Those seeking to improve longevity should focus on evidence-based factors like diet, exercise, and sleep, not single gene variants. Conclusion: CYP2D6 is not useful for longevity – the evidence is insufficient, and any claimed benefit is mechanistic or marketing-driven.