What to watch with ApoB and Abnehmen?

ApoB (apolipoprotein B) is a direct measure of the number of atherogenic particles (LDL, VLDL, IDL) in the blood and is considered a more precise cardiovascular risk marker than LDL cholesterol alone. During weight loss (Abnehmen), blood lipids often improve, but the effect on ApoB is not always parallel to LDL-C. A calorie-restricted diet rich in unsaturated fats, fiber, and low in sugar and trans fats can lower ApoB. However, a very low-carb, high-fat diet (e.g., keto) may paradoxically increase ApoB in some individuals despite weight loss. Therefore, when losing weight, one should monitor not only weight or LDL-C but also ApoB. An ApoB level below 100 mg/dL (or below 70 mg/dL for high-risk individuals) is desirable. Evidence for the link between weight reduction and ApoB lowering is moderate (observational studies, no large RCTs specifically on ApoB). Caveat: home tests for ApoB exist but may have variable accuracy; for clinical decisions, a lab blood draw is recommended. Consult a physician if risk factors are present or values are unclear.