Is SHBG useful for Müdigkeit?

SHBG (sex hormone-binding globulin) is not a direct marker for fatigue. The provided knowledge context contains no studies linking SHBG specifically to tiredness. SHBG modulates the bioavailability of testosterone and estradiol – low SHBG may indicate insulin resistance, obesity, or fatty liver, which can indirectly contribute to fatigue. High SHBG is seen in hyperthyroidism or estrogen dominance. However, fatigue is multifactorial: sleep, stress, nutrition, iron status, thyroid, and psychological factors are more relevant. A single SHBG value without clinical context is insufficient for fatigue workup. Evidence: mechanistic/unclear. Caveat: No direct recommendation from consumer tests; medical evaluation for persistent fatigue is essential.