What role does Magnesium play in allergy?

Magnesium is involved in immune regulation and histamine release, which could theoretically influence allergic responses. Some studies suggest low magnesium levels may enhance histamine secretion, potentially worsening symptoms like itching or inflammation. However, the evidence is mostly mechanistic (cell/animal models); human clinical trials are limited and inconsistent. No official guidelines (e.g., from EFSA or DGE) recommend magnesium supplementation specifically for allergies. Correcting a deficiency is sensible, but targeted use against allergies lacks robust support. Caveat: magnesium can interact with medications; high doses carry risks. Allergy management should focus on trigger avoidance and medical treatment.