Evidence check: BDNF in the context of longevity

BDNF (Brain-Derived Neurotrophic Factor) is a protein crucial for neuronal plasticity and survival. In the longevity context, BDNF is linked to cognitive health and neuroprotection during aging. Observational studies associate lower BDNF levels with increased risk of dementia and cognitive decline. However, direct causal evidence that BDNF extends human lifespan is lacking. Lifestyle factors such as physical exercise, cognitive engagement, and certain diets (e.g., omega-3 fatty acids) can upregulate BDNF production. Direct-to-consumer DNA tests analyzing single BDNF variants have limited predictive value for individual longevity. The evidence is best described as mechanistic/observational, not clinically definitive. Be cautious of exaggerated marketing claims.