Myths vs facts: Cardio Risk Check | Herz-Kreislauf Risiko-Test and Sport

Myths vs facts about cardiovascular risk checks and sport: Many direct-to-consumer tests claim to predict heart risk from single gene variants (e.g., APOE, LPA). The reality is more nuanced: Genetic factors like Lipoprotein(a) (Lp(a)) are >90% heritable and causally linked to cardiovascular events, as highlighted by the 2025 ESC/EAS guidelines recommending universal Lp(a) screening. However, most offered SNPs explain only a small fraction of total risk. The HDL-raising hypothesis has been largely refuted by genetic and CETP inhibitor trials. Exercise consistently lowers risk but cannot fully offset a strong genetic predisposition. A DNA test alone does not replace established risk factors (lipids, blood pressure, smoking, diabetes) or medical advice. Evidence for many commercial claims is weak or purely mechanistic. Bottom line: Use validated risk scores (SCORE2) and get Lp(a) measured once in life – but do not be misled by exaggerated DNA marketing promises.