What to watch with Progesteron and fatigue?

Progesterone and fatigue: A link exists, especially during hormonal fluctuations (cycle, menopause) or with hormone therapy. Progesterone has a calming/sedative effect, which can worsen fatigue in some. Genetic variants (e.g., in progesterone receptors) are not well-established for predicting fatigue in consumer tests. Clinical hormone testing (blood/saliva) and ruling out other causes (thyroid, iron, sleep) are more relevant. Caution: progesterone supplements should only be used under medical supervision due to potential side effects. Evidence: human-moderate (observational studies, but no strong genetic prediction).