Myths vs facts: FADS1 and fertility

FADS1 encodes delta-5 desaturase, a key enzyme in polyunsaturated fatty acid (PUFA) metabolism. Some GWAS and observational studies report weak associations between FADS1 variants and fertility markers such as sperm quality, age at menopause, or PCOS risk. However, the effect is small and heavily modulated by environmental factors (diet, lifestyle). Myth: A single FADS1 SNP determines fertility or can be fully corrected by targeted supplementation (e.g., omega-3). Fact: The genetic predisposition is only one piece of the puzzle; current evidence does not support clinical recommendations. Direct-to-consumer DNA tests may report these variants, but interpretation should be cautious. No safety concerns, but beware of overblown claims. Evidence grade: GWAS/observational, not causal.