How are ADH1B and Sport related?

The relationship between ADH1B and sport is indirect and primarily linked to alcohol metabolism. ADH1B encodes alcohol dehydrogenase, which breaks down ethanol to acetaldehyde. Certain variants (e.g., rs1229984, ADH1B*2) cause faster conversion, leading to higher acetaldehyde levels, often causing discomfort and reducing alcohol intake. In a sports context, this might mean individuals with this variant drink less alcohol, potentially benefiting recovery and injury risk. However, there is no strong evidence for a direct effect of ADH1B on athletic performance (e.g., endurance or strength). Some studies have examined ADH1B in relation to exercise and metabolism, but results are inconsistent. The evidence is therefore 'mixed': human studies exist but lack clear causality. A DNA test alone is not predictive of sports ability; lifestyle, training, and nutrition are far more important.