What to watch with tTG IgA and menopause?

tTG-IgA is the primary serological marker for celiac disease. During menopause, immune changes and increased intestinal permeability may trigger or worsen celiac in susceptible women. However, there is no strong evidence that menopause directly alters tTG-IgA levels. Elevated tTG-IgA should prompt gastroenterological evaluation, as untreated celiac disease can exacerbate menopausal risks like osteoporosis and nutrient deficiencies. A negative test does not fully rule out celiac disease, especially if IgA deficiency is present. Evidence is mixed: the test itself is well-validated, but the specific link to menopause is not robustly supported. Caveat: Do not self-interpret; clinical follow-up is essential.