Histamine is a biogenic amine that acts as a signaling molecule in the body and is found in many foods. Histamine intolerance (HIT) occurs when the enzyme diamine oxidase (DAO) cannot break down histamine efficiently. Symptoms include headaches, flushing, diarrhea, and palpitations. When to see a doctor? Seek immediate care for severe reactions like difficulty breathing, swelling, or circulatory collapse – these may indicate a true allergy or anaphylaxis. Also consult a doctor (allergist, gastroenterologist) for chronic, unexplained symptoms after eating. A histamine test (blood or stool) is not diagnostic alone; diagnosis typically relies on symptom diaries and elimination diets. MyBody-X tests provide lifestyle insights, not medical diagnoses. Caveat: self-treatment with DAO supplements is controversial; only take after medical advice. Evidence level: moderate, based on clinical practice and observational studies.
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