How are FOXO3 and Langlebigkeit related?

FOXO3 is a transcription factor involved in stress resistance, cell cycle regulation, and apoptosis. Genome-wide association studies (GWAS) have linked certain variants of the FOXO3 gene, especially rs2802292, with increased odds of reaching advanced age. However, effect sizes are small and explain only a minor fraction of longevity. The MyBody-X DNA Longevity test may include FOXO3, but the provided context does not list specific markers or validation data. Thus, clinical utility for individuals is limited. Longevity is influenced by many factors including lifestyle, environment, and other genes; a single genetic test cannot provide reliable prediction. Evidence grade: GWAS (association, small effects).