Evidence check: tTG IgA in the context of longevity

tTG IgA (tissue transglutaminase antibody) is a well-established biomarker for celiac disease, not directly for longevity. The evidence for diagnosing celiac disease is strong (human-strong), but the link to longevity is indirect and moderate. Untreated celiac disease can impair lifespan through chronic inflammation, malabsorption, and nutrient deficiencies (e.g., iron, vitamin D, B12). In the general asymptomatic population, screening for tTG IgA is controversial; guidelines recommend it only for at-risk groups (e.g., family history, type 1 diabetes). A positive test requires confirmation by duodenal biopsy. False positives can occur in other autoimmune conditions or infections. In the context of longevity, tTG IgA is not a routine marker; it is more relevant for investigating digestive complaints or unexplained deficiencies. A negative test does not rule out non-celiac gluten sensitivity. For comprehensive longevity assessment, markers like HbA1c, hs-CRP, vitamin D, omega-3 index, and hormone panels are more informative. The MyBody-X Men’s Wellness Check does not include tTG IgA; it focuses on metabolic and hormonal markers. In summary, tTG IgA is a specific diagnostic tool whose longevity relevance stems from preventing complications of undiagnosed celiac disease – not a direct longevity biomarker.