Myths vs facts: tTG IgA and Abnehmen

tTG IgA (tissue transglutaminase IgA) is a well-established biomarker for celiac disease, not for weight loss. Fact: In untreated celiac disease, malabsorption can lead to weight loss – a positive tTG IgA test points to the condition. Myth: A positive test alone does not mean that a gluten-free diet will automatically cause weight loss. Many people without celiac disease get tested for tTG IgA hoping to diagnose 'gluten sensitivity' and lose weight. Evidence shows tTG IgA is validated only for celiac screening (sensitivity ~95%, specificity ~98%). False positives occur (e.g., in autoimmune or liver diseases). A gluten-free diet without celiac disease is not proven for weight reduction and may cause nutrient deficiencies. For weight loss, focus on calorie balance, not tTG IgA tests. Caveat: The test is useful when celiac disease is suspected, but not as a 'weight loss tool'. Evidence: human-strong for celiac diagnosis, but marketing/unclear for weight loss.