Myths vs facts: VKORC1 and Allergie

VKORC1 encodes vitamin K epoxide reductase, a key enzyme in vitamin K metabolism and blood coagulation. It is well known for its role in warfarin sensitivity. The claim that VKORC1 variants directly influence allergies is not supported by scientific evidence. Allergies are primarily driven by IgE-mediated responses to environmental allergens, involving genes such as FCER1A, HLA, and IL-13. VKORC1 has no established function in allergology. Some direct-to-consumer genetic tests misleadingly suggest a link to sell products, but this is marketing, not evidence-based medicine. For genuine allergy assessment, IgE blood tests or skin prick tests performed by a physician remain the gold standard. A genetic test for VKORC1 provides no relevant information for allergies.