Can COMT help with longevity?

Whether the COMT gene can help with longevity is not well established. COMT (catechol-O-methyltransferase) is involved in breaking down catecholamines (dopamine, adrenaline) and metabolizing estrogens. Some research links the common Val158Met polymorphism to cognitive aging, stress resilience, and possibly estrogen-related cancer risk—factors that could influence healthspan. However, effect sizes are small, findings are inconsistent, and no direct evidence shows that COMT variants extend maximum lifespan. Most data come from mechanistic or observational studies, not clinical trials. A DNA test for COMT (e.g., from MyBody-X) may provide lifestyle insights but cannot reliably predict longevity. For evidence-based longevity, focus on diet, exercise, sleep, and stress management. Evidence level: mechanistic/unclear.