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Can Insulin help with longevity?

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Can Insulin help with longevity?

Whether insulin can help with longevity is a nuanced question. In model organisms (worms, flies, mice), reduced insulin/IGF-1 signaling (IIS) extends lifespan, suggesting that lower insulin activity is pro-longevity. However, in humans, the relationship is more complex: chronic hyperinsulinemia (high insulin) due to insulin resistance is linked to metabolic disease, inflammation, and accelerated aging. Therapeutic insulin for diabetics is essential for survival but not a longevity intervention. There is no evidence that supplemental insulin promotes longevity in healthy individuals; on the contrary, it may increase risks. Consumer tests like MyBody-X can measure insulin levels, but these are not diagnostic for longevity. The provided context does not directly address insulin and longevity; it mentions 'deregulated nutrient sensing' as a hallmark of aging, which includes IIS. Evidence is mechanistic/unclear. Safety note: Insulin is a prescription drug; misuse can cause severe hypoglycemia. Consult a physician before any intervention.

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