What role does FOXO3 play in Langlebigkeit?

FOXO3 is a transcription factor regulating stress resistance, DNA repair, and energy metabolism. Multiple large GWAS studies have consistently linked a variant (rs2802292) in the FOXO3 gene to exceptional longevity, especially in centenarians. The effect size is moderate but well-replicated. The mechanism involves enhanced autophagy and antioxidant defense. The provided context does not contain specific information on FOXO3, so this answer relies on general scientific consensus. Consumer DNA tests that include FOXO3 typically report a risk category, not a clinical diagnosis. Lifestyle factors such as caloric restriction and exercise can modulate FOXO3 activity, but individual predictive power remains limited. Evidence grade: human-strong.