Myths vs facts: Zöliakie Test and fatigue

Myth: A DNA test (e.g., from MyBody-X) can diagnose celiac disease or explain why you are fatigued. Fact: Celiac disease is diagnosed through specific blood tests (tTG-IgA) and duodenal biopsy. Genetic testing for HLA-DQ2/DQ8 can rule out celiac with high certainty but cannot confirm it – many healthy individuals carry these variants. Fatigue is a common symptom of celiac but is non-specific; it may result from malabsorption, anemia, or other causes. Direct-to-consumer tests often overstate their value. The evidence for clinical diagnosis is strong, but for consumer genetic tests it is weak. Anyone with persistent fatigue and digestive issues should see a doctor rather than rely on a home test.