Can Progesteron help with Müdigkeit?

Progesterone is a female sex hormone primarily secreted in the second half of the menstrual cycle. Some women report subjective improvement in fatigue when taking progesterone – for example, during premenstrual syndrome (PMS) or menopause. However, the scientific evidence for a direct anti-fatigue effect is weak to mixed. Progesterone acts on the central nervous system and can have sleep-promoting effects, which might indirectly influence daytime tiredness. Yet large, controlled trials demonstrating a clear causal link to reduced fatigue are lacking. Uncontrolled use of progesterone can cause side effects such as dizziness, headache, or mood swings. For persistent fatigue, common causes like iron deficiency, hypothyroidism, vitamin B12 deficiency, or sleep disorders should be medically evaluated first. Hormone testing (e.g., saliva or blood) can measure progesterone levels, but interpretation is complex and requires an endocrinologist. MyBody-X does not offer direct progesterone measurement; its tests focus on nutrients, DNA, and metabolism. Therefore, progesterone is not a general remedy for fatigue. Its use should only be considered under medical supervision and for specific indications. Evidence: mechanistic but clinically insufficient.