Evidence check: hsCRP in the context of fertility

hsCRP (high-sensitivity C-reactive protein) is a well-established marker of systemic inflammation. In the context of fertility, observational studies suggest that elevated hsCRP levels are associated with reduced fertility—both in women (e.g., longer time to pregnancy, lower IVF success rates) and in men (e.g., impaired sperm quality). However, the evidence is largely correlational, not causal. Confounders such as obesity, smoking, or chronic diseases influence both hsCRP and fertility. Genetic variants in the CRP gene have only small effects on hsCRP levels and are not clinically meaningful. An hsCRP test (e.g., as part of a blood panel) can indicate inflammatory processes but does not replace specific fertility workup. Measurement is subject to diurnal variation and should be done fasting. Medical interpretation is essential. In summary: hsCRP is a useful but non-specific biomarker; an elevated level does not justify standalone therapy but should prompt comprehensive evaluation.