What role does COMT play in Haut?

COMT (catechol-O-methyltransferase) is an enzyme that breaks down catecholamines and catechol estrogens. In the skin, it may influence inflammation, pigmentation, and oxidative stress. Some studies suggest links between COMT variants (e.g., rs4680, Val158Met) and skin conditions like melasma or premature aging, but the evidence is weak and mostly mechanistic. No strong clinical relevance for skin health has been established. DNA tests for COMT provide only suggestive insights, not diagnoses. Further research is needed to clarify its specific role in skin biology.