What role does HLA-DQ2 play in Wechseljahre?

HLA-DQ2 is a well-established genetic risk factor for celiac disease, not directly for menopause. However, undiagnosed celiac disease can influence menopause through malabsorption (e.g., calcium, vitamin D) or autoimmune mechanisms, potentially affecting bone health, hormone levels, or symptom severity. The link is indirect and based on observational data; no strong evidence supports a direct role of HLA-DQ2 in menopausal timing or symptoms. A positive HLA-DQ2 test indicates genetic susceptibility to celiac disease, not menopause. Menopause is primarily driven by hormonal changes, lifestyle, and overall health. Caution: overinterpretation of genetic tests is common. A negative test rules out celiac disease with high confidence but provides no menopause-related information. Evidence: unclear.