Testosterone and blood sugar are closely linked. Testosterone acts as an insulin sensitizer – low levels can promote insulin resistance, raising blood glucose. In men with hypogonadism, testosterone therapy may improve insulin sensitivity, but effects vary. In women, excess testosterone (e.g., PCOS) can impair glucose tolerance. Direct-to-consumer tests for testosterone-related SNPs (e.g., SHBG) have limited predictive value for blood sugar control. A continuous glucose monitor (CGM) provides far more actionable data than any single genetic test. Caution: high-dose testosterone boosters (e.g., DHEA) can affect blood sugar and carry risks. Anyone on testosterone therapy or with diabetes should monitor glucose regularly. Evidence is based on observational studies and mechanistic understanding, not on validated DTC genetic tests. Always consult a physician before starting or adjusting hormone therapy.
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