Evidence check: Folsäure in the context of fertility

The question about folic acid (vitamin B9) in the context of fertility is relevant, but the evidence requires careful interpretation. Folic acid is critical for DNA synthesis and cell division, making it essential during early pregnancy to prevent neural tube defects. For female fertility itself (conception probability), observational studies suggest that adequate folic acid intake may support ovulatory function and reduce the risk of anovulation. However, randomized controlled trials have not shown a clear effect on pregnancy rates. In men, folic acid is often combined with zinc to improve sperm quality, but the data are conflicting – some studies show modest improvements in sperm count, others show no benefit. The recommended dose for women planning pregnancy is 400–800 µg/day, starting at least four weeks before conception. Higher doses (above 1 mg) should only be used under medical supervision for specific risk factors (e.g., MTHFR variants), as they can mask vitamin B12 deficiency. The provided context does not include specific studies on folic acid and fertility, so this answer is based on general guidelines. Evidence: human-moderate.