What role does COMT play in Müdigkeit?

COMT breaks down catecholamines like dopamine and norepinephrine. Reduced enzyme activity (e.g., Val158Met) can raise dopamine levels, potentially boosting short-term performance but also contributing to fatigue via dysregulated stress response and oxidative load. Evidence is moderate: associations with fatigue exist but are small and context-dependent (e.g., sleep, stress). A DNA test alone cannot predict fatigue; lifestyle factors are more important.