The relationship between folic acid (vitamin B9) and fertility is well-recognized, though the evidence is largely observational. Folic acid is critical for DNA synthesis and cell division, processes essential for oocyte maturation and early embryonic development. Deficiency is strongly linked to neural tube defects, which is why supplementation is standard before and during pregnancy. Some studies suggest adequate folate intake may improve ovulation rates and reduce the risk of recurrent miscarriage. In men, folic acid may also support sperm quality. However, randomized controlled trials show only modest effects. The AMH level mentioned in your context (0.8 ng/mL) reflects ovarian reserve, not folate status. Genetic variants such as rs7579 in the MTHFR gene can affect folate metabolism, making personalized dosing relevant. Overall, folic acid is an important but not sole determinant of fertility. Evidence is moderate, based on human observational studies and clinical practice. Caveat: Do not exceed 1 mg daily without medical supervision, as high doses may have adverse effects.
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