How are Magnesium and allergy related?

The relationship between magnesium and allergy is not well-established in clinical research. Magnesium is involved in histamine release from mast cells and smooth muscle relaxation, which are relevant to allergic reactions. Some observational studies suggest lower magnesium levels in individuals with allergies, but the evidence is weak and inconsistent. There are no robust randomized trials showing that magnesium supplementation prevents or treats allergies. Magnesium may offer mild symptom relief for some people with hay fever or asthma, but it should not replace standard allergy treatments. High supplemental doses (above 350 mg/day) can cause diarrhea and gastrointestinal upset; caution is needed in kidney disease. Consumer DNA tests cannot provide actionable insights on magnesium status or allergy risk. The evidence is primarily mechanistic and indirect. For personalized advice, consult a healthcare professional.