Evidence check: FUT2 in the context of Langlebigkeit

The FUT2 variant rs1047781 determines secretor status and influences gut microbiome composition. However, direct evidence linking it to longevity is lacking. Non-secretors may have altered infection risk and metabolic profiles, which could theoretically affect healthspan, but effect sizes are small and dominated by lifestyle factors. Evidence comes from observational/GWAS studies, not from longevity-specific trials. Thus, FUT2 is not a validated longevity gene. Consumers should interpret such DNA results cautiously: secretor status alone does not predict lifespan. For longevity optimization, comprehensive biomarkers (e.g., inflammation, metabolic health) and professional guidance are more relevant.