Evidence check: VKORC1 in the context of fertility

VKORC1 encodes vitamin K epoxide reductase complex subunit 1, primarily known for its role in warfarin metabolism. In the context of fertility, there is currently no strong scientific evidence directly linking VKORC1 variants to fertility outcomes. Some research explores vitamin K-dependent proteins in placental or endometrial function, but findings are preliminary and inconsistent. Most associations come from population genetics without clinical validation. If a consumer DNA test includes VKORC1 in a fertility panel, it is likely an exploratory or pharmacogenetic marker rather than a proven fertility predictor. The evidence level is unclear. Consumers should be cautious: such tests often overstate the relevance of single genes for complex traits like fertility. A healthcare professional should evaluate any genetic findings in the broader clinical context. At present, VKORC1 testing is not recommended for fertility assessment.