How are FOXO3 and Wechseljahre related?

FOXO3 is a key longevity gene that regulates cellular stress resistance and autophagy via the insulin/IGF-1 pathway. Some GWAS studies suggest an association between FOXO3 variants and age at menopause, but the evidence is moderate and not fully consistent. Menopause timing is strongly influenced by ovarian reserve, hormonal status, and lifestyle; FOXO3 likely plays a modulating but not deterministic role. No direct clinical recommendations can be drawn from current data. Research is still exploratory, and individual genetic testing for FOXO3 should not be used as a standalone guide for menopause-related health decisions.