How are HDL and gut health related?

The relationship between HDL cholesterol and gut health is complex and increasingly studied. A healthy gut microbiome can positively influence HDL levels by producing short-chain fatty acids (e.g., butyrate), which stimulate hepatic HDL synthesis and strengthen the intestinal barrier. Conversely, HDL has anti-inflammatory properties that may support gut health. However, this link is based mostly on animal and mechanistic studies; large randomized human trials are lacking. The evidence is therefore moderate. Direct-to-consumer tests claiming personalized insights into HDL and gut health are not currently validated. A balanced diet rich in fiber, fermented foods, and healthy fats supports both the microbiome and HDL levels – without the need for genetic testing.