Is NutriCare | INFINITY DNA-Test useful for Müdigkeit?

The NutriCare | INFINITY DNA-Test is marketed as a comprehensive analysis that can reveal genetic predispositions related to fatigue. However, the scientific evidence for a clinically meaningful benefit in fatigue is weak. Fatigue is a multifactorial symptom that can result from sleep deprivation, stress, iron deficiency, thyroid dysfunction, infections, or mental health conditions. DNA tests can identify single gene variants (e.g., in MTHFR, FUT2, VDR, BDNF) associated with nutrient metabolism or neurotransmitter function, but effect sizes are generally small and insufficient to guide diagnosis or treatment. Most of these markers lack validated clinical cut-offs and are not recommended by professional societies for routine fatigue workup. Furthermore, no randomized controlled trials demonstrate that genotype-guided supplementation significantly improves fatigue outcomes. The test may provide ancillary information but does not replace a standard medical evaluation. Without prior blood tests (e.g., ferritin, vitamin B12, vitamin D, TSH) and clinical history, its utility is questionable. The evidence level is best described as 'marketing' or 'mixed'.