Myths vs facts: Selen and stress

Selenium is an essential trace element that acts as a cofactor for glutathione peroxidases and thioredoxin reductases, enzymes that buffer oxidative stress. Some human studies suggest that adequate selenium status can improve antioxidant capacity and lower oxidative stress biomarkers. However, evidence for a direct effect on psychological stress is weak; most research focuses on physical or cellular oxidative stress. Selenium deficiency is rare, and overdosing (e.g., via supplements) can cause selenosis. The idea that selenium alone reduces stress is therefore a myth. A balanced diet with selenium-rich foods (e.g., Brazil nuts, fish, eggs) is sensible, but supplements should only be taken if deficiency is confirmed. The evidence base is moderate, relying mostly on observational and mechanistic studies.