What to watch with Cortisol and longevity?

Cortisol, the primary stress hormone, is closely linked to longevity. Chronically elevated cortisol – due to chronic stress, poor sleep, or inflammation – is associated with accelerated cellular aging, shortened telomeres, insulin resistance, and cognitive decline. Key is not just the absolute level but the circadian rhythm: a healthy morning peak and evening trough are critical. Disrupted rhythms are considered risk factors for metabolic and cardiovascular diseases. Evidence is mostly observational; long-term RCTs directly linking cortisol reduction to lifespan extension are lacking. Measurement methods (saliva, blood, urine) have limitations – single-point readings are unreliable. Practical recommendations include stress management, adequate sleep, exercise, and an anti-inflammatory diet. DNA tests can examine genes like NR3C1 or FKBP5 that influence cortisol sensitivity, but clinical utility is low. Beware of marketing that frames cortisol as a sole 'longevity booster.' MyBody-X analysis offers lifestyle-oriented insights but does not replace medical diagnostics.