Can IgG help with Langlebigkeit?

Whether IgG (immunoglobulin G) can promote longevity is not well supported by current evidence. IgG is a key antibody of the adaptive immune system, and its levels and function change with age (immunosenescence). Some observational studies link low IgG subclasses to increased infection risk in older adults, but direct causal effects on lifespan are unproven. Supplements or therapies claiming to modulate IgG for anti-aging (e.g., collagen hydrolysate, certain probiotics) rely mostly on mechanistic or animal data. No robust human trials demonstrate that altering IgG extends longevity. Individual IgG variation is heavily influenced by genetics, infections, and vaccination status. At present, IgG is not a validated biomarker or target for longevity. Proven strategies like balanced nutrition, exercise, and risk factor management remain far more reliable.