What role does BDNF play in Haut?

BDNF (Brain-Derived Neurotrophic Factor) is a neurotrophin critical for neuronal survival and plasticity in the central nervous system. In the skin, BDNF is expressed by keratinocytes, fibroblasts, and melanocytes. It promotes wound healing, regulates melanocyte function (thus pigmentation), and modulates inflammatory responses. However, the evidence for its role in skin health is largely mechanistic, derived from cell and animal studies. Human data are limited and often associative. Consumer DNA tests that claim to assess skin aging or collagen production based on BDNF variants lack clinical validation. No professional dermatology guidelines currently recommend BDNF testing. Sun protection, diet, and lifestyle factors have a much stronger impact on skin health than common BDNF polymorphisms. Therefore, any direct consumer claims about BDNF and skin should be viewed with caution.