Can HLA-DQ2 help with Müdigkeit?

HLA-DQ2 is a genetic risk marker for celiac disease. Undiagnosed celiac disease can cause fatigue due to chronic inflammation and malabsorption. However, most HLA-DQ2 carriers do not develop celiac disease – the gene is necessary but not sufficient. Therefore, knowing your HLA-DQ2 status alone does not directly help with fatigue. It may serve as a clue: if you have persistent fatigue and other symptoms, a medical workup for celiac disease (antibody tests, biopsy) is warranted. The test is only meaningful if you are consuming gluten. Evidence linking HLA-DQ2 directly to fatigue is indirect via celiac disease; no strong studies show a standalone effect. For the general population, the utility is limited. Always consult a physician before starting a gluten-free diet.